How should Europe deal with the COVID-19 pandemic in the future? Which strategies should be pursued and what specific risks should be considered? In September 2021, we published a call in the Lancet for closer European collaboration in addressing the COVID-19 pandemic. Together with this call in the Lancet, we published an expert opinion paper […]
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This study evaluates the performance of the antigen based anterior nasal screening programme that was used at Austrian schools to detect SARS-CoV-2 infections. We combined nationwide antigen-based screening data obtained in March 2021 from 5,370 schools (Grade 1 to 8) with an RT-qPCR-based prospective cohort study comprising a representative sample of 244 schools. Considering a […]
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There is much debate about the role of schools and children in the SARS-CoV-2 pandemic. In a consortium of four Austrian universities (Medical University of Innsbruck, Medical University of Graz, Medical Faculty of the JKU Linz, University of Vienna), we set out to reliably quantify the prevalence of SARS-CoV-2 infections at schools detected with reverse-transcription […]
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Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we meta-analysed prospective studies of body-mass index, limiting confounding and reverse causality by restricting analyses to never-smokers and excluding pre-existing disease and the first 5 years of follow-up. Of 10 625 411 participants in Asia, Australia and New Zealand, Europe, and […]
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Cardiometabolic diseases often occur in one and the same individual. In this paper published in JAMA, we aimed to estimate by how much life expectancy is reduced in individuals suffering from cardiometabolic multimorbidity. In our analysis, we calculated mortality rates and hazard ratios (HRs) adjusted for age and sex using individual participant data from the […]
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Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular disease. In this paper published in JACC we aimed to investigate whether Lp(a) modifies clinical risk assessment in the general community. We measured Lp(a) in 826 men and women (age range, 45 to 84 years) and recorded incidence of cardiovascular diseases over 15 years of follow-up. […]
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Leading on from our work on telomeres in the Bruneck Study, we have conducted in this paper published in the BMJ a systematic review and meta-analysis to assess the association between leucocyte telomere length and cardiovascular risk. Our analysis included studies published up to March 2014 identified through searches of Medline, Web of Science, and […]
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Recommendations about the limits for low risk for alcohol consumption vary substantially across different national guidelines. In this large collaborative paper published in the Lancet, we aimed to define thresholds associated with lowest risk for mortality and cardiovascular disease, by analysis of data from 599912 drinkers without previous cardiovascular disease. In our analysis, we combined […]
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Current guidelines for primary prevention of cardiovascular diseases focus on the prediction of coronary heart disease and stroke. However, in a significant proportion of people, heart failure is the first presentation of cardiovascular disease, which is not included in prediction models. In this study published in Lancet Diabetes & Endocrinology, we aimed to test whether […]
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Frequent sauna bathing is associated with a reduced risk of stroke, according to a new international study. In a 15-year follow-up study, people taking a sauna 4-7 times a week were 61% less likely to suffer a stroke than those taking a sauna once a week. This is the first prospective large-scale study on this […]
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